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[A case of chronic enteropathy associated with SLCO2A1 gene diagnosed by capsule endoscopy and successfully treated by ferric carboxymaltose].
Harada, Akira; Umeno, Junji; Morisaki, Shinji; Saiki, Takuto; Taniguchi, Yoshiaki; Suzuki, Toshiyuki; Matsuno, Yuichi; Fuyuno, Yuta; Torisu, Takehiro; Suekane, Hiroshi.
Afiliação
  • Harada A; Department of Gastroenterology, Yamaguchi Red Cross Hospital.
  • Umeno J; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University.
  • Morisaki S; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University.
  • Saiki T; Department of Gastroenterology, Yamaguchi Red Cross Hospital.
  • Taniguchi Y; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University.
  • Suzuki T; Department of Gastroenterology, Yamaguchi Red Cross Hospital.
  • Matsuno Y; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University.
  • Fuyuno Y; Department of Gastroenterology, Yamaguchi Red Cross Hospital.
  • Torisu T; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University.
  • Suekane H; Department of Gastroenterology, Yamaguchi Red Cross Hospital.
Nihon Shokakibyo Gakkai Zasshi ; 119(7): 651-657, 2022.
Article em Ja | MEDLINE | ID: mdl-35811122
Chronic non-specific multiple ulcers of the small intestine is a disease condition postulated in Japan. It is an uncommon gastrointestinal disease that causes chronic anemia and hypoalbuminemia by causing numerous ulcers without any histopathologically identifiable features. In recent years, it has been revealed that the mutations of SLCO2A1, which codes the prostaglandin transporter protein, are the cause of this disease;it is called the new name "chronic enteropathy associated with SLCO2A1 gene." The ileum, except the terminal ileum, is the most common place making it difficult to identify major lesions. Other than conservative treatments, such as nutrition therapy and iron supplements, no effective treatment has been identified so far. We present a case of chronic non-specific multiple ulcers of the small intestine diagnosed by capsule endoscopy and effectively treated by ferric carboxymaltose. A 48-year-old female had chronic iron deficiency anemia since around the age of 15. Because of severe anemia, the patient had upper and lower endoscopy at the age of 47 to find the source of the bleeding, but it was not detected. Except for the terminal ileum, the capsule endoscopy revealed ring-like ulcers, tape-like ulcers, and oblique ulcer scars in the ileum. Genetic analysis showed a homozygous mutation in intron 7, c.940+1G>A, indicating a definitive diagnosis of non-specific multiple ulcers of the small intestine. Anemia and anemia-related symptoms such as general malaise persisted despite continuous oral administration of iron drugs. Three intravenous injections of ferric carboxymaltose increased hemoglobin and enhanced the symptoms.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Anemia Ferropriva / Transportadores de Ânions Orgânicos / Endoscopia por Cápsula / Anemia Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: Ja Revista: Nihon Shokakibyo Gakkai Zasshi Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Anemia Ferropriva / Transportadores de Ânions Orgânicos / Endoscopia por Cápsula / Anemia Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: Ja Revista: Nihon Shokakibyo Gakkai Zasshi Ano de publicação: 2022 Tipo de documento: Article