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AACR Project GENIE: 100,000 Cases and Beyond.
Pugh, Trevor J; Bell, Jonathan L; Bruce, Jeff P; Doherty, Gary J; Galvin, Matthew; Green, Michelle F; Hunter-Zinck, Haley; Kumari, Priti; Lenoue-Newton, Michele L; Li, Marilyn M; Lindsay, James; Mazor, Tali; Ovalle, Andrea; Sammut, Stephen-John; Schultz, Nikolaus; Yu, Thomas V; Sweeney, Shawn M; Bernard, Brady.
Afiliação
  • Pugh TJ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Bell JL; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Bruce JP; University of Toronto, Toronto, Ontario, Canada.
  • Doherty GJ; Duke University Medical Center, Durham, North Carolina.
  • Galvin M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Green MF; Cancer Research United Kingdom (CRUK) Cambridge Centre, Cambridge, United Kingdom.
  • Hunter-Zinck H; Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
  • Kumari P; Earle A. Chiles Research Institute, Portland, Oregon.
  • Lenoue-Newton ML; Providence Cancer Institute, Portland, Oregon.
  • Li MM; Duke University Medical Center, Durham, North Carolina.
  • Lindsay J; Sage Bionetworks, Seattle, Washington.
  • Mazor T; Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Ovalle A; Vanderbilt University Medical Center, Nashville, Tennessee.
  • Sammut SJ; Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
  • Schultz N; The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Yu TV; University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Sweeney SM; Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Bernard B; Dana-Farber Cancer Institute, Boston, Massachusetts.
Cancer Discov ; 12(9): 2044-2057, 2022 09 02.
Article em En | MEDLINE | ID: mdl-35819403
The American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) is an international pan-cancer registry with the goal to inform cancer research and clinical care worldwide. Founded in late 2015, the milestone GENIE 9.1-public release contains data from >110,000 tumors from >100,000 people treated at 19 cancer centers from the United States, Canada, the United Kingdom, France, the Netherlands, and Spain. Here, we demonstrate the use of these real-world data, harmonized through a centralized data resource, to accurately predict enrollment on genome-guided trials, discover driver alterations in rare tumors, and identify cancer types without actionable mutations that could benefit from comprehensive genomic analysis. The extensible data infrastructure and governance framework support additional deep patient phenotyping through biopharmaceutical collaborations and expansion to include new data types such as cell-free DNA sequencing. AACR Project GENIE continues to serve a global precision medicine knowledge base of increasing impact to inform clinical decision-making and bring together cancer researchers internationally. SIGNIFICANCE: AACR Project GENIE has now accrued data from >110,000 tumors, placing it among the largest repository of publicly available, clinically annotated genomic data in the world. GENIE has emerged as a powerful resource to evaluate genome-guided clinical trial design, uncover drivers of cancer subtypes, and inform real-world use of genomic data. This article is highlighted in the In This Issue feature, p. 2007.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Nucleicos Livres / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Cancer Discov Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Nucleicos Livres / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Cancer Discov Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá