Efficacy and tolerability of three topical acne treatments by body mass index: post hoc analysis including overweight and obese patients.
J Dermatolog Treat
; 33(6): 2790-2799, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-35833564
ABSTRACT
BACKGROUND:
Acne prevalence may be higher in overweight/obese individuals, potentially due to hormonal, inflammatory, and/or dietary factors. However, the effects of body mass index (BMI) on topical acne treatments are largely unknown.METHODS:
Post hoc analyses of changes in inflammatory/noninflammatory lesions and treatment success were conducted using phase 3 data clindamycin phosphate/benzoyl peroxide (CP/BPO) 1.2%/3.75% gel (NCT01701024); tretinoin 0.05% lotion (NCT02965456 and NCT02932306; pooled); and tazarotene 0.045% lotion (NCT03168321 and NCT03168334; pooled). Data were analyzed by BMI subgroups <25kg/m2 (underweight-to-normal), 25-<30kg/m2 (overweight), and ≥30kg/m2 (obese).RESULTS:
Among participants analyzed (CP/BPO = 495; tretinoin = 1,636; tazarotene = 1,612), â¼20-25% were overweight and 15-20% were obese. At week 12, mean percent changes from baseline in inflammatory lesions were CP/BPO (overweight -63.2%, obese -56.0%); tretinoin (-57.6%, -53.1%); tazarotene (-59.9%, -56.8%). Mean changes in noninflammatory lesions were CP/BPO (-54.2%, -50.8%); tretinoin (-51.6%, -44.9%); tazarotene (-56.7%, -54.6%). Treatment success rates with active treatment ranged from 16.2% to 33.5% across BMI groups.CONCLUSIONS:
CP/BPO 1.2%/3.75% gel, tretinoin 0.05% lotion, and tazarotene 0.045% lotion were all effective in reducing acne lesions by ≥45% in overweight/obese patients with moderate-to-severe acne, comparable to the underweight-to-normal group. Efficacy of these topical acne treatments is not greatly impacted by BMI and may be affected more by the formulation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acne Vulgar
/
Fármacos Dermatológicos
Tipo de estudo:
Clinical_trials
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Dermatolog Treat
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos