Autoimmunity and SARS-CoV-2 infection: Unraveling the link in neurological disorders.
Eur J Immunol
; 52(10): 1561-1571, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35833748
According to the World Health Organization, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already infected more than 400 million people and caused over 5 million deaths globally. The infection is associated with a wide spectrum of clinical manifestations, ranging from no signs of illness to severe pathological complications that go beyond the typical respiratory symptoms. On this note, new-onset neurological and neuropsychiatric syndromes have been increasingly reported in a large fraction of COVID-19 patients, thus potentially representing a significant public health threat. Although the underlying pathophysiological mechanisms remain elusive, a growing body of evidence suggests that SARS-CoV-2 infection may trigger an autoimmune response, which could potentially contribute to the establishment and/or exacerbation of neurological disorders in COVID-19 patients. Shedding light on this aspect is urgently needed for the development of effective therapeutic intervention. This review highlights the current knowledge of the immune responses occurring in Neuro-COVID patients and discusses potential immune-mediated mechanisms by which SARS-CoV-2 infection may trigger neurological complications.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
COVID-19
/
Doenças do Sistema Nervoso
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Suíça