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Dendritic Cells and Macrophages in the Pathogenesis of Psoriasis.
Kamata, Masahiro; Tada, Yayoi.
Afiliação
  • Kamata M; Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
  • Tada Y; Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
Front Immunol ; 13: 941071, 2022.
Article em En | MEDLINE | ID: mdl-35837394
Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. This disease impairs patients' quality of life enormously. Pathological findings demonstrate proliferation and abnormal differentiation of keratinocytes and massive infiltration of inflammatory immune cells. The pathogenesis of psoriasis is complicated. Among immune cells, dendritic cells play a pivotal role in the development of psoriasis in both the initiation and the maintenance phases. In addition, it has been indicated that macrophages contribute to the pathogenesis of psoriasis especially in the initiation phase, although studies on macrophages are limited. In this article, we review the roles of dendritic cells and macrophages in the pathogenesis of psoriasis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Qualidade de Vida Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Qualidade de Vida Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão