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Effect of risperidone on serum IL-6 levels in individuals with schizophrenia: a systematic review and meta-analysis.
Ramos-Méndez, Miguel Angel; Tovilla-Zárate, Carlos Alfonso; Juárez-Rojop, Isela Esther; Villar-Soto, Mario; Genis-Mendoza, Alma Delia; González-Castro, Thelma Beatriz; López-Narváez, María Lilia; Martínez-Magaña, José Jaime; Castillo-Avila, Rosa Giannina; Villar-Juárez, Guillermo Efrén.
Afiliação
  • Ramos-Méndez MA; División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Mexico.
  • Tovilla-Zárate CA; División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Mexico.
  • Juárez-Rojop IE; División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Mexico.
  • Villar-Soto M; Hospital Regional de Alta Especialidad de Salud Mental, Villahermosa, Mexico.
  • Genis-Mendoza AD; Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de México, Mexico.
  • González-Castro TB; División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Mexico.
  • López-Narváez ML; Hospital Chiapas Nos Une Dr. Gilberto Gómez Maza, Secretaría de Salud de Chiapas, Tuxtla Gutiérrez, Mexico.
  • Martínez-Magaña JJ; Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de México, Mexico.
  • Castillo-Avila RG; División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Mexico.
  • Villar-Juárez GE; Escuela de Ciencias de la Salud, Universidad Anáhuac Querétaro, Querétaro, Mexico.
Int J Psychiatry Clin Pract ; 27(2): 171-178, 2023 Jun.
Article em En | MEDLINE | ID: mdl-35839173
BACKGROUND: Risperidone has been significant correlated with a direct effect of interleukin-6 (IL-6) levels in patients with schizophrenia. This fact allows the opportunity to link the probable immunomodulatory effect of antipsychotic medication. Specially, a proper functioning of IL-6 pathway plays a potential role in the treatment or development of schizophrenia. OBJECTIVE: Our primary aim was to perform a systematic review and meta-analysis to determine the effect of risperidone on IL-6 levels in individuals with schizophrenia. METHODS: Studies were identified through a systematic search using PubMed, Scopus, and Web of Science databases. The articles found were subjected to the inclusion and exclusion criteria; then, the mean and standardised differences were extracted to calculate the standardised mean differences using the CMA software. RESULTS: IL-6 levels in individuals with schizophrenia were compared before and after receiving risperidone as treatment. Increased levels of IL-6 levels were observed in individuals with schizophrenia who received risperidone (point estimate 0.249, lower limit 0.042, upper limit 0.455, p-value 0.018). In the Asian population sub-analysis, no statistically significant differences were observed (point estimate 0.103, lower limit -0.187, upper limit 0.215, p value 0.890). When we compared individuals with schizophrenia to the control groups, a significant increase of IL-6 levels was observed in the group with schizophrenia (point estimate 0.248, lower limit 0.024, upper limit 0.472, p-value 0.30). CONCLUSIONS: Risperidone appears to play an important role in IL-6 levels in schizophrenia. Potential implications of increased IL-6 levels in people with schizophrenia should be considered in future studies.KEY POINTSIncreased levels of IL-6 levels were observed in individuals with schizophrenia who received risperidone.Risperidone appears to play an important role in IL-6 levels in schizophrenia.This study could serve for future research focussed on IL-6.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Antipsicóticos Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Int J Psychiatry Clin Pract Ano de publicação: 2023 Tipo de documento: Article País de afiliação: México

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Antipsicóticos Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Int J Psychiatry Clin Pract Ano de publicação: 2023 Tipo de documento: Article País de afiliação: México