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Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy.
Ma, Shijun; Zhao, Yue; Lee, Wee Chyan; Ong, Li-Teng; Lee, Puay Leng; Jiang, Zemin; Oguz, Gokce; Niu, Zhitong; Liu, Min; Goh, Jian Yuan; Wang, Wenyu; Bustos, Matias A; Ehmsen, Sidse; Ramasamy, Adaikalavan; Hoon, Dave S B; Ditzel, Henrik J; Tan, Ern Yu; Chen, Qingfeng; Yu, Qiang.
Afiliação
  • Ma S; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.
  • Zhao Y; Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore.
  • Lee WC; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.
  • Ong LT; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.
  • Lee PL; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.
  • Jiang Z; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.
  • Oguz G; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.
  • Niu Z; The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.
  • Liu M; Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore.
  • Goh JY; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.
  • Wang W; The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.
  • Bustos MA; Department of Translational Molecular Medicine, Saint John's Cancer Institute, Providence Health System, Santa Monica, CA, 90404, USA.
  • Ehmsen S; Department of Oncology, Odense University Hospital, Odense, 5230, Denmark.
  • Ramasamy A; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.
  • Hoon DSB; Department of Translational Molecular Medicine, Saint John's Cancer Institute, Providence Health System, Santa Monica, CA, 90404, USA.
  • Ditzel HJ; Department of Oncology, Odense University Hospital, Odense, 5230, Denmark.
  • Tan EY; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, 5230, Denmark.
  • Chen Q; Department of General Surgery, Tan Tock Seng Hospital, Singapore, 308433, Singapore.
  • Yu Q; Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore. qchen@imcb.a-star.edu.sg.
Nat Commun ; 13(1): 4118, 2022 07 15.
Article em En | MEDLINE | ID: mdl-35840558
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Singapura
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Singapura