Myasthenia gravis in pregnancy: Systematic review and case series.
Obstet Med
; 15(2): 108-117, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-35845224
ABSTRACT
Background:
Myasthenia gravis is an autoimmune disease which can impact pregnancy.Methods:
Six databases were systematically searched for studies with at least five subjects reporting pregnancy outcomes for women with myasthenia gravis in pregnancy. Assessment of bias was performed for all included studies. Forty-eight cases from our own centre were also included in the analysis.Results:
In total, 32 publications met inclusion criteria for systematic review, for a total of 33 unique data sets including 48 cases from our institution. Outcome data was available for 824 pregnancies. Spontaneous vaginal delivery occurred in 56.3% of pregnancies. Overall risk of myasthenia gravis exacerbation was 33.8% with a 6.4% risk of myasthenic crisis in pregnancy and 8.2% postpartum. The incidence risk of transient neonatal myasthenia gravis was 13.0%.Conclusions:
The current systematic review provides the best estimates of risk currently available to aid in counselling women with myasthenia gravis in pregnancy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Systematic_reviews
Idioma:
En
Revista:
Obstet Med
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Canadá