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Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial.
Krijbolder, Doortje I; Verstappen, Marloes; van Dijk, Bastiaan T; Dakkak, Yousra J; Burgers, Leonie E; Boer, Aleid C; Park, Yune Jung; de Witt-Luth, Marianne E; Visser, Karen; Kok, Marc R; Molenaar, Esmeralda T H; de Jong, Pascal H P; Böhringer, Stefan; Huizinga, Tom W J; Allaart, Cornelia F; Niemantsverdriet, Ellis; van der Helm-van Mil, Annette H M.
Afiliação
  • Krijbolder DI; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands.
  • Verstappen M; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands.
  • van Dijk BT; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands.
  • Dakkak YJ; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands.
  • Burgers LE; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands.
  • Boer AC; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands.
  • Park YJ; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands; Department of Rheumatology, St Vincent's Hospital, The Catholic University of Korea, Seoul, South Korea.
  • de Witt-Luth ME; Department of Rheumatology, Reinier de Graaf Hospital, Delft, Netherlands.
  • Visser K; Department of Rheumatology, Haga Hospital, The Hague, Netherlands.
  • Kok MR; Department of Rheumatology and Clinical Immunology, Maasstad Hospital, Rotterdam, Netherlands.
  • Molenaar ETH; Department of Rheumatology, Groene Hart Hospital, Gouda, Netherlands.
  • de Jong PHP; Department of Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands.
  • Böhringer S; Department of Biomedical Data Sciences, Medical Statistics Section, Leiden University Medical Centre, Leiden, Netherlands; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands.
  • Huizinga TWJ; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands.
  • Allaart CF; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands.
  • Niemantsverdriet E; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands.
  • van der Helm-van Mil AHM; Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands; Department of Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands. Electronic address: a.h.m.van_der_helm@lumc.nl.
Lancet ; 400(10348): 283-294, 2022 07 23.
Article em En | MEDLINE | ID: mdl-35871815
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Antirreumáticos Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Lancet Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Antirreumáticos Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Lancet Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda