The emergence of the calvarial hematopoietic niche in health and disease.
Immunol Rev
; 311(1): 26-38, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35880587
ABSTRACT
The diploë region of skull has recently been discovered to act as a myeloid cell reservoir to the underlying meninges. The presence of ossified vascular channels traversing the inner skull of cortex provides a passageway for the cells to traffic from the niche, and CNS-derived antigens traveling through cerebrospinal fluid in a perivascular manner reaches the niche to signal myeloid cell egress. This review will highlight the recent findings establishing this burgeoning field along with the known role this niche plays in CNS aging and disease. It will further highlight the anatomical routes and physiological properties of the vascular structures these cells use for trafficking, spanning from skull to brain parenchyma.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Células Mieloides
Limite:
Humans
Idioma:
En
Revista:
Immunol Rev
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos