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Na2S-Mediated One-Pot Selective Deoxygenation of α-Hydroxyl Carbonyl Compounds including Natural Products.
Xu, Xiaobo; Yan, Leyu; Zhang, Zhi-Kai; Lu, Bingqing; Guo, Zhuangwen; Chen, Mengyue; Cao, Zhong-Yan.
Afiliação
  • Xu X; College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China.
  • Yan L; College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China.
  • Zhang ZK; College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China.
  • Lu B; College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China.
  • Guo Z; College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China.
  • Chen M; College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China.
  • Cao ZY; College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China.
Molecules ; 27(15)2022 Jul 22.
Article em En | MEDLINE | ID: mdl-35897854
A practical method for the deoxygenation of α-hydroxyl carbonyl compounds under mild reaction conditions is reported here. The use of cheap and easy-to-handle Na2S·9H2O as the reductant in the presence of PPh3 and N-chlorosuccinimide (NCS) enables the selective dehydroxylation of α-hydroxyl carbonyl compounds, including ketones, esters, amides, imides and nitrile groups. The synthetic utility is demonstrated by the late-stage deoxygenation of bioactive molecule and complex natural products.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China