Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.

Li, Xiaoli; Li, Qianqian; Xiong, Bin; Chen, Huiling; Wang, Xiaochun; Zhang, Dekui

Li, Xiaoli; Li, Qianqian; Xiong, Bin; Chen, Huiling; Wang, Xiaochun; Zhang, Dekui.

Afiliação

Li X; Department of Gastroenterology, The Second Clinical Medical College of Lanzhou University, LanZhou University Second Hospital, Lanzhou, China.
Li Q; Department of Gastroenterology, The Second Clinical Medical College of Lanzhou University, LanZhou University Second Hospital, Lanzhou, China.
Xiong B; Department of Gastroenterology, The Second Clinical Medical College of Lanzhou University, LanZhou University Second Hospital, Lanzhou, China.
Chen H; Department of Gastroenterology, The Second Clinical Medical College of Lanzhou University, LanZhou University Second Hospital, Lanzhou, China.
Wang X; Department of Gastroenterology, The Second Clinical Medical College of Lanzhou University, LanZhou University Second Hospital, Lanzhou, China.
Zhang D; Department of Gastroenterology, The Second Clinical Medical College of Lanzhou University, LanZhou University Second Hospital, Lanzhou, China; Key Laboratory of Digestive Diseases, LanZhou University Second Hospital, Lanzhou, China. Electronic address: zhangdk8616@126.com.

Pharmacol Res ; 183: 106368, 2022 09.

Article em En | MEDLINE | ID: mdl-35905891

Assuntos

Colite Ulcerativa; Colite; Receptor com Domínio Discoidina 1; Animais; Apoptose; Colite/induzido quimicamente; Colite/genética; Colite/metabolismo; Colite Ulcerativa/genética; Colite Ulcerativa/metabolismo; Sulfato de Dextrana/farmacologia; Receptor com Domínio Discoidina 1/genética; Receptor com Domínio Discoidina 1/metabolismo; Modelos Animais de Doenças; Epitélio; Humanos; Mucosa Intestinal/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/metabolismo; Proteínas de Junções Íntimas/genética; Proteínas de Junções Íntimas/metabolismo; Junções Íntimas/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Colitis; DDR1; Intestinal mucosal barrier

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Colite / Receptor com Domínio Discoidina 1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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