Systemic single administration of anti-inflammatory microRNA 146a-5p loaded in polymeric nanomedicines with active targetability attenuates neointimal hyperplasia by controlling inflammation in injured arteries in a rat model.

Sano, Masaya; Akagi, Daisuke; Naito, Mitsuru; Hoshina, Katsuyuki; Miyata, Kanjiro; Kataoka, Kazunori; Ishihara, Soichiro

Sano, Masaya; Akagi, Daisuke; Naito, Mitsuru; Hoshina, Katsuyuki; Miyata, Kanjiro; Kataoka, Kazunori; Ishihara, Soichiro.

Afiliação

Sano M; Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku Tokyo, Japan.
Akagi D; Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku Tokyo, Japan.
Naito M; Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku Tokyo, Japan.
Hoshina K; Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku Tokyo, Japan.
Miyata K; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku Tokyo, Japan.
Kataoka K; Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Japan.
Ishihara S; Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku Tokyo, Japan.

FASEB J ; 36(9): e22486, 2022 09.

Article em En | MEDLINE | ID: mdl-35929425

Assuntos

Lesões das Artérias Carótidas; MicroRNAs; Animais; Anti-Inflamatórios/metabolismo; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; Artérias; Lesões das Artérias Carótidas/metabolismo; Proliferação de Células; Citocinas/metabolismo; Feminino; Hiperplasia/metabolismo; Inflamação/metabolismo; Masculino; MicroRNAs/metabolismo; Músculo Liso Vascular/metabolismo; NF-kappa B/metabolismo; Nanomedicina; Neointima/tratamento farmacológico; Neointima/metabolismo; Neointima/prevenção & controle; Ratos

Palavras-chave

anti-inflammatory effect; miR146a-5p; microRNA; nanomedicine; neointimal hyperplasia; polyion complex micelle

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões das Artérias Carótidas / MicroRNAs Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão

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