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Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication.
Kladnik, Jerneja; Dolinar, Ana; Kljun, Jakob; Perea, David; Grau-Expósito, Judith; Genescà, Meritxell; Novinec, Marko; Buzon, Maria J; Turel, Iztok.
Afiliação
  • Kladnik J; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.
  • Dolinar A; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.
  • Kljun J; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.
  • Perea D; Infectious Diseases Department, Vall d'Hebron Research Institute (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, VHIR Task Force COVID-19, Barcelona, Spain.
  • Grau-Expósito J; Infectious Diseases Department, Vall d'Hebron Research Institute (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, VHIR Task Force COVID-19, Barcelona, Spain.
  • Genescà M; Infectious Diseases Department, Vall d'Hebron Research Institute (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, VHIR Task Force COVID-19, Barcelona, Spain.
  • Novinec M; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.
  • Buzon MJ; Infectious Diseases Department, Vall d'Hebron Research Institute (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, VHIR Task Force COVID-19, Barcelona, Spain.
  • Turel I; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.
J Enzyme Inhib Med Chem ; 37(1): 2158-2168, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35943189
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio / Tratamento Farmacológico da COVID-19 Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Eslovênia
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio / Tratamento Farmacológico da COVID-19 Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Eslovênia