Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling.

Ozawa, Koya; Muller, Matthew A; Varlamov, Oleg; Hagen, Matthew W; Packwood, William; Morgan, Terry K; Xie, Aris; López, Claudia S; Chung, Dominic; Chen, Junmei; López, José A; Lindner, Jonathan R

Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling.

Ozawa, Koya; Muller, Matthew A; Varlamov, Oleg; Hagen, Matthew W; Packwood, William; Morgan, Terry K; Xie, Aris; López, Claudia S; Chung, Dominic; Chen, Junmei; López, José A; Lindner, Jonathan R.

Afiliação

Ozawa K; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Muller MA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Varlamov O; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, USA.
Hagen MW; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Packwood W; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Morgan TK; Department of Pathology, Oregon Health & Science University, Portland, Oregon, USA.
Xie A; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.
López CS; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Chung D; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.
Chen J; BloodWorks NW, Seattle, Washington, USA.
López JA; BloodWorks NW, Seattle, Washington, USA.
Lindner JR; BloodWorks NW, Seattle, Washington, USA.

JACC Basic Transl Sci ; 7(7): 642-655, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35958695

Palavras-chave

AS, aortic valve stenosis; MMP, matrix metalloproteinase; PMV, platelet microvesicles; TGF, transforming growth factor; VEC, valvular endothelial cell; VIC, valvular interstitial cell; WSD, Western-style diet; aortic valve stenosis; echocardiography; pSMAD2, phosphorylated SMAD2; vWF, von Willebrand factor; von Willebrand factor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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