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High-performance miniature linear time-of-flight mass spectrometry as an advantageous tool in a high mass-to-charge range.
Chang, Ko-Keng; Cai, Yi-Hong; Hsiao, Chih-Hao; Hsu, Cheng-Chih; Wang, Yi-Sheng.
Afiliação
  • Chang KK; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan. wer@gate.sinica.edu.tw.
  • Cai YH; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
  • Hsiao CH; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan. wer@gate.sinica.edu.tw.
  • Hsu CC; Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan.
  • Wang YS; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan. wer@gate.sinica.edu.tw.
Analyst ; 147(18): 4116-4123, 2022 Sep 12.
Article em En | MEDLINE | ID: mdl-35971964
A miniature matrix-assisted laser desorption/ionization linear time-of-flight mass spectrometer suitable for the high mass-to-charge (m/z) region is described. The instrument size is roughly 1/50th that of regular instruments, and detailed dimensions and experimental parameters were optimized based on the comprehensive calculation method to provide satisfactory mass resolving power. Observations showed that the performance is limited in the low m/z range and becomes comparable with that of regular instruments in the mid m/z range. In the high m/z range, the miniature instrument provides better mass resolving power and sensitivity than regular instruments, showing superior performance for microbial, protein conjugate, and polymer analyses.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Idioma: En Revista: Analyst Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Idioma: En Revista: Analyst Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Taiwan