Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors.

Harrison, David; Bock, Mark G; Doedens, John R; Gabel, Christopher A; Holloway, M Katharine; Lewis, Arwel; Scanlon, Jane; Sharpe, Andrew; Simpson, Iain D; Smolak, Pamela; Wishart, Grant; Watt, Alan P

Harrison, David; Bock, Mark G; Doedens, John R; Gabel, Christopher A; Holloway, M Katharine; Lewis, Arwel; Scanlon, Jane; Sharpe, Andrew; Simpson, Iain D; Smolak, Pamela; Wishart, Grant; Watt, Alan P.

Afiliação

Harrison D; NodThera Ltd., Suite 8, The Mansion, Chesterford Research Park, Little Chesterford, Saffron Walden, EssexCB10 1XL, United Kingdom.
Bock MG; NodThera Inc., 430 Bedford Street, Lexington, Massachusetts02420, United States.
Doedens JR; NodThera Inc., 454 N 34th Street, Seattle, Washington98103, United States.
Gabel CA; NodThera Inc., 454 N 34th Street, Seattle, Washington98103, United States.
Holloway MK; Gfree Bio LLC, 10601 Ranch Road 2222, Austin, Texas78730, United States.
Lewis A; Charles River Laboratories, Chesterford Research Park, Little Chesterford, Saffron Walden, EssexCB10 1XL, United Kingdom.
Scanlon J; NodThera Ltd., Suite 8, The Mansion, Chesterford Research Park, Little Chesterford, Saffron Walden, EssexCB10 1XL, United Kingdom.
Sharpe A; Charles River Laboratories, Chesterford Research Park, Little Chesterford, Saffron Walden, EssexCB10 1XL, United Kingdom.
Simpson ID; Charles River Laboratories, Chesterford Research Park, Little Chesterford, Saffron Walden, EssexCB10 1XL, United Kingdom.
Smolak P; NodThera Inc., 454 N 34th Street, Seattle, Washington98103, United States.
Wishart G; Charles River Laboratories, Chesterford Research Park, Little Chesterford, Saffron Walden, EssexCB10 1XL, United Kingdom.
Watt AP; NodThera Ltd., Suite 8, The Mansion, Chesterford Research Park, Little Chesterford, Saffron Walden, EssexCB10 1XL, United Kingdom.

ACS Med Chem Lett ; 13(8): 1321-1328, 2022 Aug 11.

Article em En | MEDLINE | ID: mdl-35978696

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

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