Templated Generation of a Bcl-x<sub>L</sub> Inhibitor by Isomer-Free SPAAC Based on Azacyclonon-5-yne.

Brauer, Juliane; Mötzing, Marina; Gröst, Corinna; Hoffmann, Ralf; Berg, Thorsten

Templated Generation of a Bcl-x_L Inhibitor by Isomer-Free SPAAC Based on Azacyclonon-5-yne.

Brauer, Juliane; Mötzing, Marina; Gröst, Corinna; Hoffmann, Ralf; Berg, Thorsten.

Afiliação

Brauer J; Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103, Leipzig, Germany.
Mötzing M; Institute of Bioanalytical Chemistry and, Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platzâ5, 04103, Leipzig, Germany.
Gröst C; Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103, Leipzig, Germany.
Hoffmann R; Institute of Bioanalytical Chemistry and, Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platzâ5, 04103, Leipzig, Germany.
Berg T; Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103, Leipzig, Germany.

Chemistry ; 28(66): e202202259, 2022 Nov 25.

Article em En | MEDLINE | ID: mdl-35989238

Assuntos

Alcinos; Azidas; Alcinos/química; Azidas/química; Proteína bcl-X; Química Click; Reação de Cicloadição

Palavras-chave

azides; cycloalkynes; inhibitors; protein-protein interactions; strain-promoted cycloadditions

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azidas / Alcinos Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha

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