Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA.

Bradley, Kennedy; Le-Mahajan, Audrey; Morris, Beth; Peritz, Tiina; Chiller, Tom; Forsberg, Kaitlin; Nunnally, Natalie S; Lockhart, Shawn R; Gold, Jeremy A W; Gould, Jane M

Bradley, Kennedy; Le-Mahajan, Audrey; Morris, Beth; Peritz, Tiina; Chiller, Tom; Forsberg, Kaitlin; Nunnally, Natalie S; Lockhart, Shawn R; Gold, Jeremy A W; Gould, Jane M.

Emerg Infect Dis ; 28(9): 1904-1905, 2022 09.

Article em En | MEDLINE | ID: mdl-35997507

ABSTRACT

ABSTRACT

We report a fatal infection in a 65-year-old immunocompromised male patient caused by pan-triazole-resistant Aspergillus fumigatus containing a TR34/L98H genetic mutation linked to agricultural fungicide use. Clinical and environmental surveillance of triazole-resistant A. fumigatus is needed in the United States to prevent spread and guide healthcare and agricultural practices.

Assuntos

Aspergillus fumigatus; Fungicidas Industriais; Idoso; Antifúngicos/farmacologia; Antifúngicos/uso terapêutico; Aspergillus fumigatus/genética; Azóis; Sistema Enzimático do Citocromo P-450/genética; Farmacorresistência Fúngica/genética; Proteínas Fúngicas/genética; Fungicidas Industriais/farmacologia; Humanos; Masculino; Testes de Sensibilidade Microbiana; Pennsylvania; Triazóis/farmacologia

Palavras-chave

Aspergillus fumigatus; Fungi; Pennsylvania; United States; agriculture; antifungal drug resistance; antimicrobial resistance; invasive mold infection; respiratory infections; triazoles

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Fungicidas Industriais Tipo de estudo: Risk_factors_studies Limite: Aged / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Emerg Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2022 Tipo de documento: Article

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