Sterols in asthma.

Guerau-de-Arellano, Mireia; Britt, Rodney D

Sterols in asthma.

Guerau-de-Arellano, Mireia; Britt, Rodney D.

Afiliação

Guerau-de-Arellano M; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Department of Neuroscience, The Ohio State University, Columbus, OH, USA. Electronic address: mireia.guerau@osumc.edu.
Britt RD; Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.

Trends Immunol ; 43(10): 792-799, 2022 10.

Article em En | MEDLINE | ID: mdl-36041950

ABSTRACT

ABSTRACT

While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.

Assuntos

Asma; Inibidores de Hidroximetilglutaril-CoA Redutases; Humanos; Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia; Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico; Esteróis

Palavras-chave

Th17; asthma; neutrophilic; severe; statin; sterol

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Inibidores de Hidroximetilglutaril-CoA Redutases Limite: Humans Idioma: En Revista: Trends Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article

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