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A pharmacological strategy to recapitulate exercise-induced antitumoral immunity.
Rébillard, Amélie; Nunès, Jacques A; Carrier, Alice.
Afiliação
  • Rébillard A; M2S-EA7470, University of Rennes, Rennes, France; Institut Universitaire de France (IUF), Paris, France; French Network for Nutrition and Cancer Research (NACRe network), Jouy-en-Josas, France. Electronic address: amelie.rebillard@univ-rennes2.fr.
  • Nunès JA; French Network for Nutrition and Cancer Research (NACRe network), Jouy-en-Josas, France; Aix Marseille Univ, Inserm, CNRS, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France. Electronic address: jacques.nunes@inserm.fr.
  • Carrier A; French Network for Nutrition and Cancer Research (NACRe network), Jouy-en-Josas, France; Aix Marseille Univ, Inserm, CNRS, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France. Electronic address: alice.carrier@inserm.fr.
Trends Pharmacol Sci ; 43(12): 1001-1003, 2022 12.
Article em En | MEDLINE | ID: mdl-36049970
ABSTRACT
The antitumor activity of exercise by means of enhanced immune activation is documented, but better identification of the underlying mechanisms is required to develop new therapeutic strategies. Recent work from the Dr Bar-Sagi group reveals that exercise engages IL-15 signaling and pharmacological activation of the IL-15/IL-15R axis mimics the exercise-driven immune cell-mediated cytotoxicity in pancreatic cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Interleucina-15 Limite: Humans Idioma: En Revista: Trends Pharmacol Sci Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Interleucina-15 Limite: Humans Idioma: En Revista: Trends Pharmacol Sci Ano de publicação: 2022 Tipo de documento: Article