Errors of the Egg: The Establishment and Progression of Human Aneuploidy Research in the Maternal Germline.
Annu Rev Genet
; 56: 369-390, 2022 11 30.
Article
em En
| MEDLINE
| ID: mdl-36055648
ABSTRACT
Meiosis, a key process in the creation of haploid gametes, is a complex cellular division incorporating unique timing and intricate chromosome dynamics. Abnormalities in this elaborate dance can lead to the production of aneuploid gametes, i.e., eggs containing an incorrect number of chromosomes, many of which cannot generate a viable pregnancy. For many decades, research has been attempting to address why this process is notoriously error prone in humans compared to many other organisms. Rapidly developing technologies, access to new clinical material, and a mounting public infertility crisis have kept the field both active and quickly evolving. In this review, we discuss the history of aneuploidy in humans with a focus on its origins in maternal meiosis. We also gather current working mechanistic hypotheses, as well as up-and-coming areas of interest that point to future scientific avenues and their potential clinical applications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Germinativas
/
Aneuploidia
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Annu Rev Genet
Ano de publicação:
2022
Tipo de documento:
Article