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Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 Inhibitors.
Argikar, Upendra; Blatter, Markus; Bednarczyk, Dallas; Chen, Zhuoliang; Cho, Young Shin; Doré, Michaël; Dumouchel, Jennifer L; Ho, Samuel; Hoegenauer, Klemens; Kawanami, Toshio; Mathieu, Simon; Meredith, Erik; Möbitz, Henrik; Murphy, Stephen K; Parthasarathy, Saravanan; Soldermann, Carole Pissot; Santos, Jobette; Silver, Serena; Skolnik, Suzanne; Stojanovic, Aleksandar.
Afiliação
  • Argikar U; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Blatter M; Novartis Institutes for BioMedical Research, Basel 4002, Switzerland.
  • Bednarczyk D; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Chen Z; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Cho YS; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Doré M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Dumouchel JL; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Ho S; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Hoegenauer K; Novartis Institutes for BioMedical Research, Basel 4002, Switzerland.
  • Kawanami T; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Mathieu S; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Meredith E; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Möbitz H; Novartis Institutes for BioMedical Research, Basel 4002, Switzerland.
  • Murphy SK; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Parthasarathy S; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Soldermann CP; Novartis Institutes for BioMedical Research, Basel 4002, Switzerland.
  • Santos J; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Silver S; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Skolnik S; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.
  • Stojanovic A; Novartis Institutes for BioMedical Research, Basel 4002, Switzerland.
J Med Chem ; 65(18): 12386-12402, 2022 09 22.
Article em En | MEDLINE | ID: mdl-36069672
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Antígeno Prostático Específico Limite: Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Antígeno Prostático Específico Limite: Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos