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Histone demethylase KDM2A suppresses EGF-TSPAN8 pathway to inhibit breast cancer cell migration and invasion in vitro.
Zhang, Haomiao; Tu, Yanhong; Huang, Bin; Xiao, Jianpeng; Xiao, Jie; Wang, Jie; Pei, Yujie; Yang, Ruifang; Feng, Jing; Li, Jing; Zhang, Xueli.
Afiliação
  • Zhang H; The Third School of Clinical Medicine, Southern Medical University, Guangdong Province, Guangzhou, 510515, China; Department of General Surgery, Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China.
  • Tu Y; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangdong Province, Guangzhou, 510515, China.
  • Huang B; Department of General Surgery, Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China; Anhui University of Science and Technology Affiliated Fengxian Hospital, Shanghai, 201499, China.
  • Xiao J; The Third School of Clinical Medicine, Southern Medical University, Guangdong Province, Guangzhou, 510515, China.
  • Xiao J; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangdong Province, Guangzhou, 510515, China.
  • Wang J; The Third School of Clinical Medicine, Southern Medical University, Guangdong Province, Guangzhou, 510515, China.
  • Pei Y; Anhui University of Science and Technology Affiliated Fengxian Hospital, Shanghai, 201499, China.
  • Yang R; Anhui University of Science and Technology Affiliated Fengxian Hospital, Shanghai, 201499, China.
  • Feng J; The Third School of Clinical Medicine, Southern Medical University, Guangdong Province, Guangzhou, 510515, China; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangdong Province, Guangzhou, 510515, China; The Second Affiliated Hospital, The Chinese University of Hong
  • Li J; School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangdong Province, Guangzhou, 510515, China; Anhui University of Science and Technology Affiliated Fengxian Hospital, Shanghai, 201499, China; Department of Laboratory Medicine & Central Laboratory, Southern Medical U
  • Zhang X; The Third School of Clinical Medicine, Southern Medical University, Guangdong Province, Guangzhou, 510515, China; Department of General Surgery, Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China; Department of Laboratory Medicine & Central Laboratory, Southern Med
Biochem Biophys Res Commun ; 628: 104-109, 2022 11 05.
Article em En | MEDLINE | ID: mdl-36084547
ABSTRACT
Metastasis is a major cause of breast cancer mortality and the current study found histone demethylase, KDM2A, expression to be negatively correlated with breast cancer metastasis. KDM2A knockdown greatly promoted migration and invasion of breast cancer cells. The histone demethylase activity of KDM2A downregulated EGF transcription and suppressed the EGF-TSPAN8 pathway. Inhibition of breast cancer cell migration was also dependent on the histone demethylase activity of KDM2A. A novel mechanism of KDM2A-suppression of the EGF-TSPAN8 pathway which inhibited breast cancer cell migration and invasion is reported.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Proteínas F-Box / Histona Desmetilases com o Domínio Jumonji Limite: Female / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Proteínas F-Box / Histona Desmetilases com o Domínio Jumonji Limite: Female / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China