Contact-mediated signaling enables disorder-driven transitions in cellular assemblies.
Phys Rev E
; 106(2): L022401, 2022 Aug.
Article
em En
| MEDLINE
| ID: mdl-36109907
We show that, when cells communicate by contact-mediated interactions, heterogeneity in cell shapes and sizes leads to qualitatively distinct collective behavior in the tissue. For intercellular coupling that implements lateral inhibition, such disorder-driven transitions can substantially alter the asymptotic pattern of differentiated cells by modulating their fate choice through changes in the neighborhood geometry. In addition, when contact-induced signals influence inherent cellular oscillations, disorder leads to the emergence of functionally relevant partially-ordered dynamical states.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Phys Rev E
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Índia