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Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
Chana, Chetan K; Maisonneuve, Pierre; Posternak, Ganna; Grinberg, Nicolas G A; Poirson, Juline; Ona, Samara M; Ceccarelli, Derek F; Mader, Pavel; St-Cyr, Daniel J; Pau, Victor; Kurinov, Igor; Tang, Xiaojing; Deng, Dongjing; Cui, Weiren; Su, Wenji; Kuai, Letian; Soll, Richard; Tyers, Mike; Röst, Hannes L; Batey, Robert A; Taipale, Mikko; Gingras, Anne-Claude; Sicheri, Frank.
Afiliação
  • Chana CK; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.
  • Maisonneuve P; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Posternak G; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.
  • Grinberg NGA; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.
  • Poirson J; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.
  • Ona SM; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Ceccarelli DF; Donnelly Centre for Cellular and Biomolecular Research, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
  • Mader P; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.
  • St-Cyr DJ; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Pau V; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.
  • Kurinov I; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.
  • Tang X; X-Chem Inc., Montréal, Québec H4S 1Z9, Canada.
  • Deng D; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.
  • Cui W; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, Illinois 60439, United States.
  • Su W; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.
  • Kuai L; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Soll R; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Tyers M; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Röst HL; WuXi AppTec, 55 Cambridge Parkway, 8th Floor, Cambridge, Massachusetts 02142, United States.
  • Batey RA; WuXi AppTec, 55 Cambridge Parkway, 8th Floor, Cambridge, Massachusetts 02142, United States.
  • Taipale M; Institute for Research in Immunology and Cancer, University of Montréal, Québec H3C 3J7, Canada.
  • Gingras AC; Donnelly Centre for Cellular and Biomolecular Research, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
  • Sicheri F; Department of Computer Science, University of Toronto, Toronto, Ontario M5S 2E4, Canada.
J Med Chem ; 65(19): 12725-12746, 2022 10 13.
Article em En | MEDLINE | ID: mdl-36117290
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Ubiquitina-Proteína Ligases Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Ubiquitina-Proteína Ligases Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá