Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms.
Chin Herb Med
; 13(1): 49-63, 2021 Jan.
Article
em En
| MEDLINE
| ID: mdl-36117755
ABSTRACT
Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients' quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties; They also have other benefits that may be relevant for ameliorating myocardial ischemia-reperfusion injury (MIRI). In this review, we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e) myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chin Herb Med
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China