Very low frequency of the lactase persistence allele LCT-13910T in the Armenian population.
Ann Hum Biol
; 49(5-6): 260-262, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-36129808
ABSTRACT
Primary lactose malabsorption is characterised by a down-regulation of lactase activity after weaning and inability to digest lactose in adulthood. It has been suggested that the historical introduction of dairying led to a positive selection for lactase persistence variants in a regulatory region upstream of the LCT gene. Here, we genotyped 202 Armenian subjects for LCT-13910T, a lactase persistence variant which is widespread in Europeans. The homozygous C/C genotype associated with primary hypolactasia, the heterozygous C/T and the homozygous T/T lactase persistence genotypes were found in 191 (94.6%), 11 (5.4%), and 0 (0.0%) samples, respectively. The frequency for the LCT-13910*T allele was 2.7%. The observed allele frequency of 2.7% for LCT-13910T is even lower than previously reported and supports current phenotypic data about lactose malabsorption in Armenia.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Intolerância à Lactose
Limite:
Adult
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Ann Hum Biol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Áustria