Estrogen Receptor Subtypes Elicit a Distinct Gene Expression Profile of Endothelial-Derived Factors Implicated in Atherosclerotic Plaque Vulnerability.

Nasiri-Ansari, Narjes; Spilioti, Eliana; Kyrou, Ioannis; Kalotychou, Vassiliki; Chatzigeorgiou, Antonios; Sanoudou, Despina; Dahlman-Wright, Karin; Randeva, Harpal S; Papavassiliou, Athanasios G; Moutsatsou, Paraskevi; Kassi, Eva

Estrogen Receptor Subtypes Elicit a Distinct Gene Expression Profile of Endothelial-Derived Factors Implicated in Atherosclerotic Plaque Vulnerability.

Nasiri-Ansari, Narjes; Spilioti, Eliana; Kyrou, Ioannis; Kalotychou, Vassiliki; Chatzigeorgiou, Antonios; Sanoudou, Despina; Dahlman-Wright, Karin; Randeva, Harpal S; Papavassiliou, Athanasios G; Moutsatsou, Paraskevi; Kassi, Eva.

Afiliação

Nasiri-Ansari N; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Spilioti E; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Kyrou I; Laboratory of Toxicological Control of Pesticides, Scientific Directorate of Pesticides' Control and Phytopharmacy, Benaki Phytopathological Institute, 14561 Athens, Greece.
Kalotychou V; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK.
Chatzigeorgiou A; Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
Sanoudou D; Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, 11855 Athens, Greece.
Dahlman-Wright K; Centre for Sport, Exercise and Life Sciences, Research Institute for Health & Wellbeing, Coventry University, Coventry CV1 5FB, UK.
Randeva HS; Department of Internal Medicine, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Papavassiliou AG; Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Moutsatsou P; Clinical Genomics and Pharmacogenomics Unit, 4th Department of Internal Medicine, Attikon Hospital Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Kassi E; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Int J Mol Sci ; 23(18)2022 Sep 19.

Article em En | MEDLINE | ID: mdl-36142876

Assuntos

Aterosclerose; Placa Aterosclerótica; Células Endoteliais/metabolismo; Estradiol/farmacologia; Receptor alfa de Estrogênio/genética; Receptor alfa de Estrogênio/metabolismo; Receptor beta de Estrogênio/genética; Estrogênios/farmacologia; Humanos; Metaloproteinase 2 da Matriz/genética; Metaloproteinase 2 da Matriz/metabolismo; Metaloproteinase 9 da Matriz/genética; Metaloproteinase 9 da Matriz/metabolismo; Placa Aterosclerótica/genética; Proteína-Lisina 6-Oxidase/metabolismo; RNA Mensageiro/metabolismo; Receptores de Estrogênio/metabolismo; Inibidor Tecidual de Metaloproteinase-1/metabolismo; Inibidor Tecidual de Metaloproteinase-2/metabolismo; Transcriptoma; Fator de Necrose Tumoral alfa/genética

Palavras-chave

GPR-30; MCP-1; atherosclerosis; endothelial cells; estrogen; estrogen receptors; matrix metalloproteinases MMPs; p21; plaque vulnerability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Grécia

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