Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A and B.
J Am Chem Soc
; 144(39): 17792-17796, 2022 10 05.
Article
em En
| MEDLINE
| ID: mdl-36150149
ABSTRACT
Ginkgolides are diterpenes isolated from Ginkgo biloba that exhibit strong anti-inflammatory and neuroprotective properties. The highly complex molecular architecture of ginkgolides, combined with their remarkable biological profile, provides a unique platform for the development of new strategies and methods. Herein, we reported the first total synthesis of ginkgolide C and the formal syntheses of ginkgolides A and B. Our synthesis is based on a functional group strategy guided by the compact structure of ginkgolide, where a series of diastereoselective carbon-carbon bond formations and oxidations are carefully orchestrated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ginkgolídeos
/
Diterpenos
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Canadá