A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes.

Lee, Han Kyu; Kwon, Do Hoon; Aylor, David L; Marchuk, Douglas A

A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes.

Lee, Han Kyu; Kwon, Do Hoon; Aylor, David L; Marchuk, Douglas A.

Afiliação

Lee HK; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: hankyu.lee@duke.edu.
Kwon DH; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Aylor DL; Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
Marchuk DA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: douglas.marchuk@duke.edu.

Am J Hum Genet ; 109(10): 1814-1827, 2022 10 06.

Article em En | MEDLINE | ID: mdl-36167069

Assuntos

AVC Isquêmico; Alelos; Animais; Encéfalo/metabolismo; Mapeamento Cromossômico; Humanos; Camundongos; Proteínas de Transporte Vesicular/genética; Proteínas rab de Ligação ao GTP/genética; Proteínas rab de Ligação ao GTP/metabolismo

Palavras-chave

coding SNPs; collateral vessels; cross-species complementation; human RABEP2; human sequence variation; infarct volume; in vivo evaluation platform; ischemic stroke

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: AVC Isquêmico Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Am J Hum Genet Ano de publicação: 2022 Tipo de documento: Article

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