Spatiotemporal lipidomics reveals key features of brain lipid dynamic changes after cerebral ischemia and reperfusion therapy.

Ma, Yinzhong; Chen, Zhiyu; He, Qianyan; Guo, Zhen-Ni; Yang, Yi; Liu, Fulin; Li, Fang; Luo, Qian; Chang, Junlei

Ma, Yinzhong; Chen, Zhiyu; He, Qianyan; Guo, Zhen-Ni; Yang, Yi; Liu, Fulin; Li, Fang; Luo, Qian; Chang, Junlei.

Afiliação

Ma Y; Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China.
Chen Z; Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing 100049, China.
He Q; Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China; Department of Neurology, the First Hospital of Jilin University, Changchun 130021, Jilin, China.
Guo ZN; Department of Neurology, the First Hospital of Jilin University, Changchun 130021, Jilin, China.
Yang Y; Department of Neurology, the First Hospital of Jilin University, Changchun 130021, Jilin, China.
Liu F; Department of Cardiac Surgery, Affiliated Hospital of Hebei University, Baoding 071000, China.
Li F; Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Luo Q; Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: qian.luo@siat.ac.cn.
Chang J; Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China. Electronic address: jl.chang@siat.ac.cn.

Pharmacol Res ; 185: 106482, 2022 11.

Article em En | MEDLINE | ID: mdl-36195305

Assuntos

Isquemia Encefálica; AVC Isquêmico; Acidente Vascular Cerebral; Animais; Camundongos; Ativador de Plasminogênio Tecidual; Lipidômica; Isquemia Encefálica/tratamento farmacológico; Reperfusão/métodos; Acidente Vascular Cerebral/tratamento farmacológico; Infarto da Artéria Cerebral Média/tratamento farmacológico; Encéfalo/metabolismo; Metabolismo dos Lipídeos; Lipídeos; Fibrinolíticos/uso terapêutico

Palavras-chave

Ischemic stroke; Lipids; Mass spectrometry imaging; Reperfusion injury; RtPA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Acidente Vascular Cerebral / AVC Isquêmico Limite: Animals Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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