Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli.

Maruta, Toyoaki; Hidaka, Kotaro; Kouroki, Satoshi; Koshida, Tomohiro; Kurogi, Mio; Kage, Yohko; Mizuno, Seiya; Shirasaka, Tetsuro; Yanagita, Toshihiko; Takahashi, Satoru; Takeya, Ryu; Tsuneyoshi, Isao

Maruta, Toyoaki; Hidaka, Kotaro; Kouroki, Satoshi; Koshida, Tomohiro; Kurogi, Mio; Kage, Yohko; Mizuno, Seiya; Shirasaka, Tetsuro; Yanagita, Toshihiko; Takahashi, Satoru; Takeya, Ryu; Tsuneyoshi, Isao.

Afiliação

Maruta T; Department of Anesthesiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Hidaka K; Department of Anesthesiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Kouroki S; Department of Anesthesiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Koshida T; Department of Anesthesiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Kurogi M; Department of Anesthesiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Kage Y; Department of Pharmacology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Mizuno S; Laboratory Animal Resource Center in Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Shirasaka T; Department of Anesthesiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Yanagita T; Department of Clinical Pharmacology, School of Nursing, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Takahashi S; Laboratory Animal Resource Center in Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Takeya R; Department of Pharmacology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Tsuneyoshi I; Department of Anesthesiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.

PLoS One ; 17(10): e0275751, 2022.

Article em En | MEDLINE | ID: mdl-36201719

Assuntos

Gânglios Espinais; Canal de Sódio Disparado por Voltagem NAV1.7/metabolismo; Optogenética; Animais; Channelrhodopsins/metabolismo; Gânglios Espinais/metabolismo; Camundongos; Camundongos Transgênicos; Dor/genética; Recombinases/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canal de Sódio Disparado por Voltagem NAV1.7 / Optogenética / Gânglios Espinais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google