Chemical tools to track and perturb the expression of sialic acid and fucose monosaccharides.
Chem Commun (Camb)
; 58(87): 12139-12150, 2022 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-36222364
ABSTRACT
The biosynthesis of glycans is a highly conserved biological process and found in all domains of life. The expression of cell surface glycans is increasingly recognized as a target for therapeutic intervention given the role of glycans in major pathologies such as cancer and microbial infection. Herein, we summarize our contributions to the development of unnatural monosaccharide derivatives to infiltrate and alter the expression of both mammalian and bacterial glycans and their therapeutic application.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Fucose
/
Monossacarídeos
Limite:
Animals
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Holanda