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Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
Reyes, Nabora S; Krasilnikov, Maria; Allen, Nancy C; Lee, Jin Young; Hyams, Ben; Zhou, Minqi; Ravishankar, Supriya; Cassandras, Monica; Wang, Chaoqun; Khan, Imran; Matatia, Peri; Johmura, Yoshikazu; Molofsky, Ari; Matthay, Michael; Nakanishi, Makoto; Sheppard, Dean; Campisi, Judith; Peng, Tien.
Afiliação
  • Reyes NS; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Krasilnikov M; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Allen NC; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Lee JY; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Hyams B; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Zhou M; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Ravishankar S; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Cassandras M; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Wang C; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Khan I; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Matatia P; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Johmura Y; Division of Cancer Cell Biology, University of Tokyo, Tokyo, Japan.
  • Molofsky A; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Matthay M; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Nakanishi M; Division of Cancer Cell Biology, University of Tokyo, Tokyo, Japan.
  • Sheppard D; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
  • Campisi J; Buck Institute for Research on Aging, Novato, CA, USA.
  • Peng T; Department of Medicine, Pulmonary and Critical Care Division, University of California San Francisco, San Francisco, CA, USA.
Science ; 378(6616): 192-201, 2022 10 14.
Article em En | MEDLINE | ID: mdl-36227993
ABSTRACT
We engineered an ultrasensitive reporter of p16INK4a, a biomarker of cellular senescence. Our reporter detected p16INK4a-expressing fibroblasts with certain senescent characteristics that appeared shortly after birth in the basement membrane adjacent to epithelial stem cells in the lung. Furthermore, these p16INK4a+ fibroblasts had enhanced capacity to sense tissue inflammation and respond through their increased secretory capacity to promote epithelial regeneration. In addition, p16INK4a expression was required in fibroblasts to enhance epithelial regeneration. This study highlights a role for p16INK4a+ fibroblasts as tissue-resident sentinels in the stem cell niche that monitor barrier integrity and rapidly respond to inflammation to promote tissue regeneration.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Senescência Celular / Genes Reporter / Inibidor p16 de Quinase Dependente de Ciclina / Células Epiteliais / Nicho de Células-Tronco / Fibroblastos / Pulmão Limite: Humans Idioma: En Revista: Science Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Senescência Celular / Genes Reporter / Inibidor p16 de Quinase Dependente de Ciclina / Células Epiteliais / Nicho de Células-Tronco / Fibroblastos / Pulmão Limite: Humans Idioma: En Revista: Science Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos