Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
Science
; 378(6616): 192-201, 2022 10 14.
Article
em En
| MEDLINE
| ID: mdl-36227993
ABSTRACT
We engineered an ultrasensitive reporter of p16INK4a, a biomarker of cellular senescence. Our reporter detected p16INK4a-expressing fibroblasts with certain senescent characteristics that appeared shortly after birth in the basement membrane adjacent to epithelial stem cells in the lung. Furthermore, these p16INK4a+ fibroblasts had enhanced capacity to sense tissue inflammation and respond through their increased secretory capacity to promote epithelial regeneration. In addition, p16INK4a expression was required in fibroblasts to enhance epithelial regeneration. This study highlights a role for p16INK4a+ fibroblasts as tissue-resident sentinels in the stem cell niche that monitor barrier integrity and rapidly respond to inflammation to promote tissue regeneration.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Senescência Celular
/
Genes Reporter
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Inibidor p16 de Quinase Dependente de Ciclina
/
Células Epiteliais
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Nicho de Células-Tronco
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Fibroblastos
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Pulmão
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos