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Validity of the NIH toolbox cognitive battery in a healthy oldest-old 85+ sample.
Nolin, Sara A; Cowart, Hannah; Merritt, Stacy; McInerney, Katalina; Bharadwaj, P K; Franchetti, Mary Kate; Raichlen, David A; Jessup, Cortney J; Hishaw, G Alex; Van Etten, Emily J; Trouard, Theodore P; Geldmacher, David S; Wadley, Virginia G; Porges, Eric S; Woods, Adam J; Cohen, Ron A; Levin, Bonnie E; Rundek, Tatjana; Alexander, Gene E; Visscher, Kristina M.
Afiliação
  • Nolin SA; University of Alabama at Birmingham, Heersink School of Medicine, Evelyn F. McKnight Brain Institute, Birmingham, AL, USA.
  • Cowart H; University of Alabama at Birmingham, Heersink School of Medicine, Evelyn F. McKnight Brain Institute, Birmingham, AL, USA.
  • Merritt S; University of Miami, Miller School of Medicine, Evelyn F. McKnight Brain Institute, Miami, FL, USA.
  • McInerney K; University of Miami, Miller School of Medicine, Evelyn F. McKnight Brain Institute, Miami, FL, USA.
  • Bharadwaj PK; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA.
  • Franchetti MK; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA.
  • Raichlen DA; University of Southern California, Los Angeles, CA, USA.
  • Jessup CJ; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA.
  • Hishaw GA; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA.
  • Van Etten EJ; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA.
  • Trouard TP; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA.
  • Geldmacher DS; University of Alabama at Birmingham, Heersink School of Medicine, Evelyn F. McKnight Brain Institute, Birmingham, AL, USA.
  • Wadley VG; University of Alabama at Birmingham, Heersink School of Medicine, Evelyn F. McKnight Brain Institute, Birmingham, AL, USA.
  • Porges ES; University of Florida, Evelyn F. and William L. McKnight Brain Institute, Gainesville, FL, USA.
  • Woods AJ; University of Florida, Evelyn F. and William L. McKnight Brain Institute, Gainesville, FL, USA.
  • Cohen RA; University of Florida, Evelyn F. and William L. McKnight Brain Institute, Gainesville, FL, USA.
  • Levin BE; University of Miami, Miller School of Medicine, Evelyn F. McKnight Brain Institute, Miami, FL, USA.
  • Rundek T; University of Miami, Miller School of Medicine, Evelyn F. McKnight Brain Institute, Miami, FL, USA.
  • Alexander GE; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA.
  • Visscher KM; University of Alabama at Birmingham, Heersink School of Medicine, Evelyn F. McKnight Brain Institute, Birmingham, AL, USA.
J Int Neuropsychol Soc ; 29(6): 605-614, 2023 Jul.
Article em En | MEDLINE | ID: mdl-36239453
ABSTRACT

OBJECTIVE:

To evaluate the construct validity of the NIH Toolbox Cognitive Battery (NIH TB-CB) in the healthy oldest-old (85+ years old).

METHOD:

Our sample from the McKnight Brain Aging Registry consists of 179 individuals, 85 to 99 years of age, screened for memory, neurological, and psychiatric disorders. Using previous research methods on a sample of 85 + y/o adults, we conducted confirmatory factor analyses on models of NIH TB-CB and same domain standard neuropsychological measures. We hypothesized the five-factor model (Reading, Vocabulary, Memory, Working Memory, and Executive/Speed) would have the best fit, consistent with younger populations. We assessed confirmatory and discriminant validity. We also evaluated demographic and computer use predictors of NIH TB-CB composite scores.

RESULTS:

Findings suggest the six-factor model (Vocabulary, Reading, Memory, Working Memory, Executive, and Speed) had a better fit than alternative models. NIH TB-CB tests had good convergent and discriminant validity, though tests in the executive functioning domain had high inter-correlations with other cognitive domains. Computer use was strongly associated with higher NIH TB-CB overall and fluid cognition composite scores.

CONCLUSION:

The NIH TB-CB is a valid assessment for the oldest-old samples, with relatively weak validity in the domain of executive functioning. Computer use's impact on composite scores could be due to the executive demands of learning to use a tablet. Strong relationships of executive function with other cognitive domains could be due to cognitive dedifferentiation. Overall, the NIH TB-CB could be useful for testing cognition in the oldest-old and the impact of aging on cognition in older populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cognição / Função Executiva Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Humans País/Região como assunto: America do norte Idioma: En Revista: J Int Neuropsychol Soc Assunto da revista: NEUROLOGIA / PSICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cognição / Função Executiva Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Humans País/Região como assunto: America do norte Idioma: En Revista: J Int Neuropsychol Soc Assunto da revista: NEUROLOGIA / PSICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos