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Prognostic value of primary tumor sidedness in patients with non-metastatic IBD related CRC - Is it the exception to the rule?
Kamphues, Carsten; Lefevre, Jeremie H; Wang, Jane; Amini, Neda; Beaugerie, Laurent; Kuehn, Florian; Park, Sang Hyoung; Andreatos, Nikolaos; Lauscher, Johannes C; Enea, Diana; Lehmann, Kai S; Peru, Nicolas; Weixler, Benjamin; Kirchgesner, Julien; Degro, Claudius E; Pozios, Ioannis; van Beekum, Cornelius J; Schölch, Sebastian; Zambonin, Daniela; Schineis, Christian; Loch, Florian N; Geka, Despoina; Theoxari, Maria; Wu, Bin; Wang, Pei-Pei; Antoniou, Efstathios; Pikoulis, Emmanouil; Moussata, Driffa; Theodoropoulos, George; Ouaissi, Mehdi; Seeliger, Hendrik; Inaba, Yosuke; Scaringi, Stefano; Reißfelder, Christoph; Vilz, Tim O; Lin, Chen; Yang, Suk-Kyun; Beyer, Katharina; Renz, Bernhard W; Sasaki, Kazunari; Margonis, Georgios Antonios; Svrcek, Magali; Kreis, Martin E.
Afiliação
  • Kamphues C; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
  • Lefevre JH; Sorbonne Université, Department of Digestive Surgery, Assistance Publique des Hôpitaux de Paris AP-HP, Hôpital Saint Antoine, Paris, France.
  • Wang J; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Amini N; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Beaugerie L; Department of Gastroenterology, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France.
  • Kuehn F; Department of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, Munich, Germany.
  • Park SH; Department of Gastroenterology and Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
  • Andreatos N; Department of Surgery and Department of Internal Medicine and Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Lauscher JC; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
  • Enea D; Sorbonne Université, Assistance Publique des Hôpitaux de Paris AP-HP, Department of Pathology, Saint-Antoine Hospital, Paris, France.
  • Lehmann KS; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
  • Peru N; Sorbonne Université, Department of Digestive Surgery, Assistance Publique des Hôpitaux de Paris AP-HP, Hôpital Saint Antoine, Paris, France.
  • Weixler B; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
  • Kirchgesner J; Department of Gastroenterology, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France.
  • Degro CE; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
  • Pozios I; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
  • van Beekum CJ; Department of Surgery, University Hospital of Bonn, Bonn, Germany.
  • Schölch S; Department of Surgery, University Medical Centre Mannheim and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Zambonin D; Department of Experimental and Clinical Medicine, IBD Unit, Careggi University Hospital, Florence, Italy.
  • Schineis C; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
  • Loch FN; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
  • Geka D; First Department of Propaedeutic Surgery, Hippokration General Hospital of Athens, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Theoxari M; First Department of Propaedeutic Surgery, Hippokration General Hospital of Athens, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Wu B; Department of General Surgery, Peking Union Medical College Hospital, Beijing, China.
  • Wang PP; Department of General Surgery, Peking Union Medical College Hospital, Beijing, China.
  • Antoniou E; Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Pikoulis E; Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Moussata D; Department of Hepato-gastroenterology, CHU Tours, France.
  • Theodoropoulos G; First Department of Propaedeutic Surgery, Hippokration General Hospital of Athens, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Ouaissi M; Department of Digestive, Oncological, Endocrine, Hepato-Biliary and Pancreatic Surgery, Liver Transplantation, Colorectal Surgery Unit, Trousseau Hospital, Tours, France.
  • Seeliger H; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
  • Inaba Y; Clinical Research Center, Chiba University Hospital, Chiba, Japan.
  • Scaringi S; Department of Experimental and Clinical Medicine, IBD Unit, Careggi University Hospital, Florence, Italy.
  • Reißfelder C; Department of Surgery, University Medical Centre Mannheim and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Vilz TO; Department of Surgery, University Hospital of Bonn, Bonn, Germany.
  • Lin C; Department of General Surgery, Peking Union Medical College Hospital, Beijing, China.
  • Yang SK; Department of Gastroenterology and Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
  • Beyer K; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
  • Renz BW; Department of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, Munich, Germany.
  • Sasaki K; Department of Surgery and Department of Internal Medicine and Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Margonis GA; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic a
  • Svrcek M; Sorbonne Université, Assistance Publique des Hôpitaux de Paris AP-HP, Department of Pathology, Saint-Antoine Hospital, Paris, France.
  • Kreis ME; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of General and Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany.
Surg Oncol ; 45: 101874, 2022 Dec.
Article em En | MEDLINE | ID: mdl-36257179
BACKGROUND: Although primary tumor sidedness (PTS) has a known prognostic role in sporadic colorectal cancer (CRC), its role in Inflammatory Bowel Disease related CRC (IBD-CRC) is largely unknown. Thus, we aimed to evaluate the prognostic role of PTS in patients with IBD-CRC. METHODS: All eligible patients with surgically treated, non-metastatic IBD-CRC were retrospectively identified from institutional databases at ten European and Asian academic centers. Long term endpoints included recurrence-free (RFS) and overall survival (OS). Multivariable Cox proportional hazard regression as well as propensity score analyses were performed to evaluate whether PTS was significantly associated with RFS and OS. RESULTS: A total of 213 patients were included in the analysis, of which 32.4% had right-sided (RS) tumors and 67.6% had left-sided (LS) tumors. PTS was not associated with OS and RFS even on univariable analysis (5-year OS for RS vs LS tumors was 68.0% vs 77.3%, respectively, p = 0.31; 5-year RFS for RS vs LS tumors was 62.8% vs 65.4%, respectively, p = 0.51). Similarly, PTS was not associated with OS and RFS on propensity score matched analysis (5-year OS for RS vs LS tumors was 82.9% vs 91.3%, p = 0.79; 5-year RFS for RS vs LS tumors was 85.1% vs 81.5%, p = 0.69). These results were maintained when OS and RFS were calculated in patients with RS vs LS tumors after excluding patients with rectal tumors (5-year OS for RS vs LS tumors was 68.0% vs 77.2%, respectively, p = 0.38; 5-year RFS for RS vs LS tumors was 62.8% vs 59.2%, respectively, p = 0.98). CONCLUSIONS: In contrast to sporadic CRC, PTS does not appear to have a prognostic role in IBD-CRC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Neoplasias Colorretais / Doenças Inflamatórias Intestinais Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Surg Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Neoplasias Colorretais / Doenças Inflamatórias Intestinais Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Surg Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha