Your browser doesn't support javascript.
loading
Investigation of Spatiotemporal Profiles of Single-Pulse TMS-Evoked Potentials with Active Stimulation Compared with a Novel Sham Condition.
Takano, Mayuko; Wada, Masataka; Zomorrodi, Reza; Taniguchi, Keita; Li, Xuemei; Honda, Shiori; Tobari, Yui; Mimura, Yu; Nakajima, Shinichiro; Kitahata, Ryosuke; Mimura, Masaru; Daskalakis, Zafiris J; Blumberger, Daniel M; Noda, Yoshihiro.
Afiliação
  • Takano M; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Wada M; Teijin Pharma Limited, Tokyo 191-8512, Japan.
  • Zomorrodi R; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Taniguchi K; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Li X; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Honda S; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Tobari Y; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Mimura Y; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Nakajima S; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Kitahata R; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Mimura M; Shinjuku-Yoyogi Mental Lab Clinic, Tokyo 151-0051, Japan.
  • Daskalakis ZJ; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Blumberger DM; Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA 92161, USA.
  • Noda Y; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Biosensors (Basel) ; 12(10)2022 Oct 01.
Article em En | MEDLINE | ID: mdl-36290951
ABSTRACT
Identifying genuine cortical stimulation-elicited electroencephalography (EEG) is crucial for improving the validity and reliability of neurophysiology using transcranial magnetic stimulation (TMS) combined with EEG. In this study, we evaluated the spatiotemporal profiles of single-pulse TMS-elicited EEG response administered to the left dorsal prefrontal cortex (DLPFC) in 28 healthy participants, employing active and sham stimulation conditions. We hypothesized that the early component of TEP would be activated in active stimulation compared with sham stimulation. We specifically analyzed the (1) stimulus response, (2) frequency modulation, and (3) phase synchronization of TMS-EEG data at the sensor level and the source level. Compared with the sham condition, the active condition induced a significant increase in TMS-elicited EEG power in the 30-60 ms time interval in the stimulation area at the sensor level. Furthermore, in the source-based analysis, the active condition induced significant increases in TMS-elicited response in the 30-60 ms compared with the sham condition. Collectively, we found that the active condition could specifically activate the early component of TEP compared with the sham condition. Thus, the TMS-EEG method that was applied to the DLPFC could detect the genuine neurophysiological cortical responses by properly handling potential confounding factors such as indirect response noises.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estimulação Magnética Transcraniana / Potenciais Evocados Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biosensors (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estimulação Magnética Transcraniana / Potenciais Evocados Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biosensors (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão