Rationalizing rules for immunotherapy combination trials: About time for precision immunotherapy.

ABSTRACT

Immunotherapy has changed the landscape of cancer treatment. However, the benefit of immunotherapy is seen only in some cases, with most patients experiencing cancer progression despite treatment with immunotherapy. To overcome this, combination immunotherapy treatments are being studied. Herein, we propose for a precision-driven approach for patient selection to identify successful combinations of immunotherapy to improve outcomes for patients with cancer.