Ginsengenin derivatives synthesized from 20(<i>R</i>)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway.

Guo, Hong-Yan; Xing, Yue; Sun, Yu-Qiao; Liu, Can; Xu, Qian; Shang, Fan-Fan; Zhang, Run-Hui; Jin, Xue-Jun; Chen, Fener; Lee, Jung Joon; Kang, Dongzhou; Shen, Qing-Kun; Quan, Zhe-Shan

Ginsengenin derivatives synthesized from 20(R)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway.

Guo, Hong-Yan; Xing, Yue; Sun, Yu-Qiao; Liu, Can; Xu, Qian; Shang, Fan-Fan; Zhang, Run-Hui; Jin, Xue-Jun; Chen, Fener; Lee, Jung Joon; Kang, Dongzhou; Shen, Qing-Kun; Quan, Zhe-Shan.

Afiliação

Guo HY; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Xing Y; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Sun YQ; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Liu C; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Xu Q; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Shang FF; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Zhang RH; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Jin XJ; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Chen F; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, China.
Lee JJ; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Kang D; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Shen QK; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.
Quan ZS; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.

J Ginseng Res ; 46(6): 738-749, 2022 Nov.

Article em En | MEDLINE | ID: mdl-36312731

Palavras-chave

20(R)-Panaxotriol; Antitumor; Bax, Bcl-2-associated X; Bcl-2, B cell lymphoma-2; DMEM, Dulbecco's modified Eagle's medium; Derivatives; EdU, 5-ethynyl-2'-deoxyuridine; FBS, fetal bovine serum; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HIF-1, hypoxia-inducible factor-1; HIF-1α; HR-MS, high-resolution mass spectra; MMP, matrix metalloproteinase; OD, optical density; PBS, phosphate-buffered saline; TLC, thin-layer chromatography; Topo, topoisomerase; VEGF, vascular endothelial growth factor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: J Ginseng Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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