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Hierarchically mesoporous Ce-based MOFs with enhanced alkaline phosphatase-like activity for phosphorylated biomarker sensing.
Gao, Rui; Ye, Niru; Kou, Xiaoxue; Shen, Yujian; Yang, Huangsheng; Wu, Tong; Huang, Siming; Chen, Guosheng; Ouyang, Gangfeng.
Afiliação
  • Gao R; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guang-zhou 510275, China. chengsh39@mail.sysu.edu.cn.
  • Ye N; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guang-zhou 510275, China. chengsh39@mail.sysu.edu.cn.
  • Kou X; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guang-zhou 510275, China. chengsh39@mail.sysu.edu.cn.
  • Shen Y; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guang-zhou 510275, China. chengsh39@mail.sysu.edu.cn.
  • Yang H; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guang-zhou 510275, China. chengsh39@mail.sysu.edu.cn.
  • Wu T; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guang-zhou 510275, China. chengsh39@mail.sysu.edu.cn.
  • Huang S; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China. huangsm@g
  • Chen G; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guang-zhou 510275, China. chengsh39@mail.sysu.edu.cn.
  • Ouyang G; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guang-zhou 510275, China. chengsh39@mail.sysu.edu.cn.
Chem Commun (Camb) ; 58(91): 12720-12723, 2022 Nov 15.
Article em En | MEDLINE | ID: mdl-36314354
ABSTRACT
Herein, we develop a hierarchically mesoporous cerium metal-organic framework (Ce-HMMOF) nanozyme with enhanced ALP-mimicking activity for the naked-eye detection of phosphorylated biomarkers. The long-range ordered mesochannels (9.18 nm) throughout the Ce-HMMOF promote both the mass transfer and the accessibility of interior active sites, permitting the rapid and sensitive sensing of phosphorylated biomarkers through ALP-like biocatalysis. This work provides a new insight into the engineering of highly active nanozymes for disease-associated biomarker screening and diagnosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cério / Estruturas Metalorgânicas Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cério / Estruturas Metalorgânicas Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China