Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.

Xu, Jie; Grosslight, Samantha; Mack, Kyle A; Nguyen, Sierra C; Clagg, Kyle; Lim, Ngiap-Kie; Timmerman, Jacob C; Shen, Jeff; White, Nicholas A; Sirois, Lauren E; Han, Chong; Zhang, Haiming; Sigman, Matthew S; Gosselin, Francis

Xu, Jie; Grosslight, Samantha; Mack, Kyle A; Nguyen, Sierra C; Clagg, Kyle; Lim, Ngiap-Kie; Timmerman, Jacob C; Shen, Jeff; White, Nicholas A; Sirois, Lauren E; Han, Chong; Zhang, Haiming; Sigman, Matthew S; Gosselin, Francis.

Afiliação

Xu J; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Grosslight S; Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
Mack KA; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Nguyen SC; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Clagg K; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Lim NK; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Timmerman JC; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Shen J; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
White NA; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Sirois LE; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Han C; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Zhang H; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Sigman MS; Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
Gosselin F; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

J Am Chem Soc ; 144(45): 20955-20963, 2022 11 16.

Article em En | MEDLINE | ID: mdl-36326518

Assuntos

Antineoplásicos; Proteínas Proto-Oncogênicas p21(ras); Modelos Lineares; Antineoplásicos/farmacologia; Quinazolinas/química; Piridinas

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Antineoplásicos Idioma: En Revista: J Am Chem Soc Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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