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In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance.
Wirth, Anna-Katharina; Wange, Lucas; Vosberg, Sebastian; Henrich, Kai-Oliver; Rausch, Christian; Özdemir, Erbey; Zeller, Christina M; Richter, Daniel; Feuchtinger, Tobias; Kaller, Markus; Hermeking, Heiko; Greif, Philipp A; Senft, Daniela; Jurinovic, Vindi; Bahrami, Ehsan; Jayavelu, Ashok Kumar; Westermann, Frank; Mann, Matthias; Enard, Wolfgang; Herold, Tobias; Jeremias, Irmela.
Afiliação
  • Wirth AK; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Wange L; Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University (LMU), Martinsried, Germany.
  • Vosberg S; Clinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
  • Henrich KO; Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Rausch C; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
  • Özdemir E; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.
  • Zeller CM; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Richter D; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Feuchtinger T; Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University (LMU), Martinsried, Germany.
  • Kaller M; Department of Pediatrics, Dr. von Hauner Children´s Hospital, University Hospital, LMU Munich, Munich, Germany.
  • Hermeking H; Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilian University (LMU), Munich, Germany.
  • Greif PA; Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilian University (LMU), Munich, Germany.
  • Senft D; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.
  • Jurinovic V; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany.
  • Bahrami E; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Jayavelu AK; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Westermann F; Department of Medicine III, and Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.
  • Mann M; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
  • Enard W; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
  • Herold T; Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center, Heidelberg, Germany.
  • Jeremias I; Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Leukemia ; 36(12): 2863-2874, 2022 12.
Article em En | MEDLINE | ID: mdl-36333584
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha