Effect of icariin in a rat model of colchicine-induced cognitive deficit: role of ß<b>-</b>amyloid proteolytic enzymes.

Omar, Eman M; Elatrebi, Soha; Soliman, Nada A H; Omar, Amira M; Allam, Eman A

Effect of icariin in a rat model of colchicine-induced cognitive deficit: role of ß-amyloid proteolytic enzymes.

Omar, Eman M; Elatrebi, Soha; Soliman, Nada A H; Omar, Amira M; Allam, Eman A.

Afiliação

Omar EM; Department of Medical Physiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Elatrebi S; Department of Clinical Pharmacology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Soliman NAH; Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Omar AM; Department of Histology & Cell Biology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Allam EA; Department of Medical Physiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Nutr Neurosci ; 26(12): 1172-1182, 2023 Dec.

Article em En | MEDLINE | ID: mdl-36342068

Assuntos

Doença de Alzheimer; Disfunção Cognitiva; Ratos; Animais; Peptídeos beta-Amiloides/metabolismo; Metaloproteinase 2 da Matriz/metabolismo; Metaloproteinase 2 da Matriz/farmacologia; Peptídeo Hidrolases/metabolismo; Peptídeo Hidrolases/farmacologia; Encéfalo/metabolismo; Disfunção Cognitiva/metabolismo; Cognição; Doença de Alzheimer/induzido quimicamente; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/metabolismo

Palavras-chave

ACSF: artificial cerebrospinal fluid; AD: Alzheimer's disease; Aß: ß amyloid; ECM: extracellular matrix; ICA: Icariin; ICV: intra-cerebro-ventricular; IDE: insulin-degrading enzyme; Icariin; MMP: matrix metalloproteinase; NEP: neprilysin; NF-κB: Nuclear factor-kappa B; insulin-degrading enzyme; matrix metalloprotinase-2; neprilysin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nutr Neurosci Assunto da revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Egito

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