Circadian rhythms and glial cells of the central nervous system.
Biol Rev Camb Philos Soc
; 98(2): 520-539, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36352529
ABSTRACT
Glial cells are the most abundant cells in the central nervous system and play crucial roles in neural development, homeostasis, immunity, and conductivity. Over the past few decades, glial cell activity in mammals has been linked to circadian rhythms, the 24-h chronobiological clocks that regulate many physiological processes. Indeed, glial cells rhythmically express clock genes that cell-autonomously regulate glial function. In addition, recent findings in rodents have revealed that disruption of the glial molecular clock could impact the entire organism. In this review, we discuss the impact of circadian rhythms on the function of the three major glial cell types - astrocytes, microglia, and oligodendrocytes - across different locations within the central nervous system. We also review recent evidence uncovering the impact of glial cells on the body's circadian rhythm. Together, this sheds new light on the involvement of glial clock machinery in various diseases.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Relógios Circadianos
Limite:
Animals
Idioma:
En
Revista:
Biol Rev Camb Philos Soc
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Canadá