Prenatal inflammation shapes microglial immune response into adulthood.

Traetta, Marianela E; Tremblay, Marie-Ève

Traetta, Marianela E; Tremblay, Marie-Ève.

Afiliação

Traetta ME; Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis' (IBCN), CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina; Facultad de Farmacia y Bioquímica, Cátedra de Farmacología, Universidad de Buenos Aires, Buenos Aires, Argentina.
Tremblay MÈ; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada. Electronic address: evetremblay@uvic.ca.

Trends Immunol ; 43(12): 953-955, 2022 12.

Article em En | MEDLINE | ID: mdl-36357264

ABSTRACT

ABSTRACT

Hayes and collaborators recently unraveled that maternal immune activation in mice led to a long-lasting decrease in microglial immune reactivity. Thus, microglia exhibited a reduced immune response to a second proinflammatory stressor in adulthood. This altered microglial response impacted both astrocytic reactivity and neuronal circuitry.

Assuntos

Inflamação; Microglia; Gravidez; Feminino; Animais; Camundongos; Imunidade

Palavras-chave

immune response; maternal immune activation; microglia; neurodegeneration; neurodevelopment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microglia / Inflamação Limite: Animals / Pregnancy Idioma: En Revista: Trends Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina

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