The efficacy of platelet-rich plasma in osseous foot and ankle pathology: a review.

The purpose of this review is to develop evidence-based practices for the use of platelet-rich plasma (PRP) to treat bony pathologies of the lower extremity. There is moderate high-quality evidence to support the use of PRP in surgery to treat damage of both cartilage and bone in the foot. The literature supports a conceivable positive impact on bony healing after fracture. There is insufficient evidence to support PRP injections in the conservative management symptomatic ankle osteoarthritis. PRP may augment bone stimulation surgery in cases of cartilage and bone defects with promise for increasing bone to bone healing following surgical operations. Further high-quality, comparative studies with longer clinical follow-up are required.