Inclusion body myositis: from genetics to clinical trials.
J Neurol
; 270(3): 1787-1797, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-36399165
ABSTRACT
Inclusion body myositis (IBM) belongs to the group of idiopathic inflammatory myopathies and is characterized by a slowly progressive disease course with asymmetric muscle weakness of predominantly the finger flexors and knee extensors. The disease leads to severe disability and most patients lose ambulation due to lack of curative or disease-modifying treatment options. Despite some genes reported to be associated with hereditary IBM (a distinct group of conditions), data on the genetic susceptibility of sporadic IBM are very limited. This review gives an overview of the disease and focuses on the current genetic knowledge and potential therapeutic implications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Miosite de Corpos de Inclusão
/
Miosite
Limite:
Humans
Idioma:
En
Revista:
J Neurol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido