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Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts.
Strand, Siri H; Rivero-Gutiérrez, Belén; Houlahan, Kathleen E; Seoane, Jose A; King, Lorraine M; Risom, Tyler; Simpson, Lunden A; Vennam, Sujay; Khan, Aziz; Cisneros, Luis; Hardman, Timothy; Harmon, Bryan; Couch, Fergus; Gallagher, Kristalyn; Kilgore, Mark; Wei, Shi; DeMichele, Angela; King, Tari; McAuliffe, Priscilla F; Nangia, Julie; Lee, Joanna; Tseng, Jennifer; Storniolo, Anna Maria; Thompson, Alastair M; Gupta, Gaorav P; Burns, Robyn; Veis, Deborah J; DeSchryver, Katherine; Zhu, Chunfang; Matusiak, Magdalena; Wang, Jason; Zhu, Shirley X; Tappenden, Jen; Ding, Daisy Yi; Zhang, Dadong; Luo, Jingqin; Jiang, Shu; Varma, Sushama; Anderson, Lauren; Straub, Cody; Srivastava, Sucheta; Curtis, Christina; Tibshirani, Rob; Angelo, Robert Michael; Hall, Allison; Owzar, Kouros; Polyak, Kornelia; Maley, Carlo; Marks, Jeffrey R; Colditz, Graham A.
Afiliação
  • Strand SH; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark.
  • Rivero-Gutiérrez B; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Houlahan KE; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Seoane JA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Vall d'Hebron Institute of Oncology, 08035 Barcelona, Spain.
  • King LM; Department of Surgery, Duke University School of Medicine, Durham, NC 27708, USA.
  • Risom T; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Simpson LA; Department of Surgery, Duke University School of Medicine, Durham, NC 27708, USA.
  • Vennam S; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Khan A; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Cisneros L; School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA.
  • Hardman T; Department of Surgery, Duke University School of Medicine, Durham, NC 27708, USA.
  • Harmon B; Department of Pathology, Montefiore Medical Center, Bronx, NY 10467, USA; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA.
  • Couch F; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Department of Pathology, Mayo Clinic, Rochester, MN 55902, USA.
  • Gallagher K; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Kilgore M; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Wei S; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • DeMichele A; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • King T; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Breast Oncology Program, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • McAuliffe PF; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  • Nangia J; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston TX 77030, USA.
  • Lee J; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Department of Surgery, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Tseng J; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
  • Storniolo AM; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
  • Thompson AM; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston TX 77030, USA; Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
  • Gupta GP; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Burns R; TBCRC Loco-Regional Working Group, Baltimore, MD 21287, USA; TBCRC, The EMMES Corporation, Rockville, MD 20850, USA.
  • Veis DJ; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63108, USA; Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • DeSchryver K; Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Zhu C; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Matusiak M; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Wang J; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Zhu SX; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Tappenden J; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Ding DY; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.
  • Zhang D; Duke Cancer Institute, Duke University School of Medicine, Durham, NC 27708, USA.
  • Luo J; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Jiang S; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Varma S; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Anderson L; Department of Surgery, Duke University School of Medicine, Durham, NC 27708, USA.
  • Straub C; Department of Surgery, Duke University School of Medicine, Durham, NC 27708, USA.
  • Srivastava S; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Curtis C; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine and Genetics, Stanford University, Stanford, CA 94305, USA.
  • Tibshirani R; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA; Department of Statistics, Stanford University, Stanford, CA 94305, USA.
  • Angelo RM; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Hall A; Department of Pathology, Duke University School of Medicine, Durham, NC 27708, USA.
  • Owzar K; Duke Cancer Institute, Duke University School of Medicine, Durham, NC 27708, USA; Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC 27708, USA.
  • Polyak K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Maley C; School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA.
  • Marks JR; Department of Surgery, Duke University School of Medicine, Durham, NC 27708, USA.
  • Colditz GA; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cancer Cell ; 40(12): 1521-1536.e7, 2022 12 12.
Article em En | MEDLINE | ID: mdl-36400020
ABSTRACT
Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from 542 patients with 7.3 years median follow-up from the Translational Breast Cancer Research Consortium 038 study and the Resource of Archival Breast Tissue cohorts. We identify 812 genes associated with ipsilateral recurrence within 5 years from treatment and develop a classifier that predicts DCIS or IBC recurrence in both cohorts. Pathways associated with recurrence include proliferation, immune response, and metabolism. Distinct stromal expression patterns and immune cell compositions are identified. Our multiscale approach employed in situ methods to generate a spatially resolved atlas of breast precancers, where complementary modalities can be directly compared and correlated with conventional pathology findings, disease states, and clinical outcome.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Carcinoma Ductal de Mama / Carcinoma Intraductal não Infiltrante Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Carcinoma Ductal de Mama / Carcinoma Intraductal não Infiltrante Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Dinamarca