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Evolution of Animal South American RVA Told by the NSP4 Gene E12 Genotype.
Miño, Samuel Orlando; Badaracco, Alejandra; Louge Uriarte, Enrique; Ciarlet, Max; Parreño, Viviana.
Afiliação
  • Miño SO; Instituto Nacional de Tecnología Agropecuaria INTA, EEA Cerro Azul, Ruta Nacional 14, km 836 (CP3313), Cerro Azul 3313, Argentina.
  • Badaracco A; Instituto Nacional de Tecnología Agropecuaria INTA, EEA Montecarlo, Av. El Libertador N° 2472 (CP3384), Montecarlo 3384, Argentina.
  • Louge Uriarte E; Instituto Nacional de Tecnología Agropecuaria INTA, EEA Balcarce, Ruta 226 km 73.5 (CP7620), Balcarce 7620, Argentina.
  • Ciarlet M; Clinical Development, Icosavax, Seattle, WA 98101, USA.
  • Parreño V; Instituto Nacional de Tecnología Agropecuaria INTA, CICVyA, INTA Castelar, De las Cabañas y De los Reseros s/n (CP1686), Hurlingham 1686, Argentina.
Viruses ; 14(11)2022 11 12.
Article em En | MEDLINE | ID: mdl-36423115
Rotavirus A (RVA) possesses a genome of 11 double-stranded (ds) RNA segments, and each segment encodes one protein, with the exception of segment 11. NSP4 is a non-structural multifunctional protein encoded by segment 10 that defines the E-genotype. From the 31 E-genotypes described, genotype E12 has been described in Argentina, Uruguay, Paraguay, and Brazil in RVA strains infecting different animal species and humans. In this work, we studied the evolutionary relationships of RVA strains carrying the E12 genotype in South America using phylogenetic and phylodynamic approaches. We found that the E12 genotype has a South American origin, with a guanaco (Lama guanicoe) strain as natural host. Interestingly, all the other reported RVA strains carrying the E12 genotype in equine, bovine, caprine, and human strains are related to RVA strains of camelid origin. The evolutionary path and genetic footprint of the E12 genotype were reconstructed starting with the introduction of non-native livestock species into the American continent with the Spanish conquest in the 16th century. The imported animal species were in close contact with South American camelids, and the offspring were exposed to the native RVA strains brought from Europe and the new RVA circulating in guanacos, resulting in the emergence of new RVA strains in the current lineages' strongly species-specific adaption. In conclusion, we proposed the NSP4 E12 genotype as a genetic geographic marker in the RVA strains circulating in different animal species in South America.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Camelídeos Americanos / Rotavirus Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Viruses Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Camelídeos Americanos / Rotavirus Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Viruses Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina